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Background: As for treating metastatic humerus, open reduction with internal fixation (ORIF),intramedullary nail fixation as well as reconstruction of endoprosthesis act as the approaches with highestfrequency in surgeries. In the current study, the postoperative complications and functional outcomes werecompared after 3 operating treatments for metastatic humerus by performing a meta-analysis.Methods: An electronic search of relevant studies was done on December 29, 2015 and rigorously screenedthem according to inclusion and exclusion criteria. The summary results of the included studies were pooledusing a random-effects mode.Results: A total of 21 studies were included for analysis. we evaluated the functional outcome according tothe MSTS score, found that the upper limb function apparently returned after surgery. For localcomplications, the overall reoperation rate after endoprosthetic reconstruction (95%CI 0.06-0.11) rangedfrom 0-14%, 0-9% after intramedullary nailing (95%CI 0.04-0.08), and 0-8% after ORIF (95%CI 0.05-0.24). The rate of re-operation for failed fixations ranged from zero to 10% after reconstruction ofendoprosthesis (95%CI 0.03-0.07), 0-6% after intramedullary nailing (95%CI 0.01-0.04), and was 0-19%in all studies after ORIF (95%CI 0.02-0.19), while that for dislocations ranged from 0% to 8% afterreconstruction of endoprosthesis (95%CI 0.02-0.05), and 0-5% after intramedullary nailing (95%CI 0.01-0.04).Conclusions: Compared with the high rate of reoperation due to ORIF, those of intramedullary nail fixationand endoprosthetic construction are of comparability. The findings in the current study is applicable foraiding to make appropriately surgical decision to improve the living quality of patients in the remainder oftheir lives.

Outcome Based on Metastatic Humerus and Surgical Fixation: Finding of a Systematic Review