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Despite its decreasing incidence, prosthesis-related infections remain a research, diagnostic, therapeutic andcost-related problem. Our study aim was to compare the diagnostic accuracy of conventional periprosthetictissue culture and culture of sonication fluid of the explanted hardware and to investigate the role of patientrelated factors affecting the sensitivity of the sonication method. We investigated 70 patients undergoingrevision hip or knee arthroplasty, at our institution. Patients’ medical history and demographiccharacteristics were recorded. We compared the culture of samples obtained by sonication of explanted hipand knee prostheses with conventional culture of periprosthetic tissue for the microbiological diagnosis ofprosthetic-joint infection. Thirty-two patients had septic loosening and 38 aseptic loosening (48 hipprostheses and 22 knee prostheses). The sensitivities of sonication fluid culture and conventional tissuecultures were 81.25% and 56.25%, respectively (p-value = 0.043). The sensitivity of the sonication methodwas statistically higher in obese, diabetic patients, with age above 60, in uncemented arthroplasties and inarthroplasties because of primary osteoarthritis (p-values &lt; 0.05). The sonication method has a greatersensitivity than the conventional periprosthetic tissue cultures for the periprosthetic infections, especially inobese, diabetic patients, with age above 60, in uncemented arthroplasties and in arthroplasties because ofprimary osteoarthritis.

clinical microbiology and research

Patient-Related Factors Affecting the Sensitivity of Sonication of Removed Hip and Knee Implants Against Conventional Tissue Cultures for Diagnosis of Prosthetic Joint Infections