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Summary In this study, 21 structurally diverse drugs with examined central nervous system penetration were used for prediction of blood-brain barrier penetration using HPLC-UV instrument. Drugs' chromatographic capacity factors were measured by the immobilized artificial membrane presented by phosphatidylcholine column. The correlation between chromatographic capacity factor, octanol-water partition coefficient (log P) and molecular polar surface area (PSA) were determined at the physiological pH. The correlation factor 0.6677 with respect to log P and 0.7199 in reference to PSA was assigned. The developed in vitro prediction method may be used as a screening tool for blood-brain barrier penetration of drugs with passive transport mechanism.

military medical science letters/vojenské zdravotnické listy

SCREENING OF BLOOD-BRAIN BARRIER PENETRATION USING THE IMMOBILIZED ARTIFICIAL MEMBRANE PHOSPHATIDYLCHOLINE COLUMN CHROMATOGRAPHY AT THE PHYSIOLOGICAL PH