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We present a new method for label-free separation of cells by rolling on patterned P-selectin receptors. P-selectin edges patterned using selective surface chemistry could direct trajectories of rolling cells along the edges leading to separation of rolling HL60 cells from non-rolling K562 cells in a microfluidic device. The displacement of the cells and hence the resolution of separation was found to be a function of the device length.

MICROFLUIDIC DEVICES FOR RAPID LABEL-FREE SEPARATION OF CELLS AND POINT-OF-CARE DIAGNOSTICS