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The first normally-closed Parylene valve operating on electrothermal principles for rapid and wireless drug delivery was designed, fabricated, modeled, and tested. This valve is a key component of an implantable microbolus infusion pump (MIP) for neuroimaging in freely-moving untethered animals. This low-power, lightweight MEMS valve enables an MIP suitable for studying functional brain activation in genetically engineered mice by replacing a large conventional solenoid valve used previously in larger animals.

A WIRELESSLY–ACTIVATED PARYLENE ELECTROTHERMAL VALVE FOR MAPPING BRAIN FUNCTION IN FREELY MOVING SUBJECTS