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We administered a highly purified icosapentaenoic acid ethyl ester (IPA-E) preparation orally for 12 weeks to 32 male and 22 female patients aged 43 to 85 (average 67 years) with arteriosclerosis to investigate the effects of various factors on changes in the levels of unsaturated fatty acid in plasma and serum lipids. On administration of 1800 mg/day of IPA-E, the plasma level of IPA increased significantly, while the plasma level of DHLA decreased significantly, but no significant changes were observed in plasma DHA and AA concentrations. There were significant inverse correlations between the pretreatment levels of plasma IPA and IPA/AA, and the volumes and ratios of changes in their plasma levels following administration of IPA-E. There was no significant correlation between patient age or concomitant administration of calcium antagonists and baseline plasma IPA level and IPA/AA value or changes in these parameters after administration of IPA-E. In male patients, the plasma IPA level before treatment was higher than that in female patients, while the increase in plasma IPA level after administration of IPA-E tended to be smaller than in female patients. In diabetic patients and those receiving diuretics concomitantly, plasma IPA/AA values before treatment with IPA-E were higher, while the increase in IPA/AA values after treatment tended to be smaller than other groups of patients. On analysis of covariance on modified baseline volume before treatment, the effect of age, sex, presence of diabetes mellitus and concurrent use of calcium antagonist or diuretics was not significant.(ABSTRACT TRUNCATED AT 250 WORDS)

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The Effect of Various Factors on Changes in the Levels of Unsaturated Fatty Acid in Plasma and Serum Lipids after Administration of Icosapentaenoic Acid Ethyl Ester.