English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Nanoparticles are systems formed by biodegradable, synthetic or natural polymers, that have gained significant importance in different industry segments, as well as being the highlight of essential researches. These tiny particles present various promising characteristics, such as: site-specific and gradual drug release and improvement of active principle solubility and stability. The combination of nanotechnology with medicinal plants could be able to enhance the action of plant extracts, such so that many innovative drug carriers have emerged, including polymeric nanoparticles. The objective of this study was to synthesize and characterize polymeric nanoparticles coated with hyaluronic acid, containing Tithonia diversifolia (Hemsl) A. Gray flowers alcoholic extract, aiming to improve the nanoparticle’s stability, for possible future applications. The synthesis occurred through emulsion polymerization, where the monomer n-butyl-cyanoacrylate was incorporated with Dextran® into an aqueous HCl solution, with posterior addition of the alcoholic plant extract and neutralization reaction with NaOH. Stability parameters, such as hydrodynamic diameter, polydispersity index, zeta potential, spectroscopy (IV), Scanning Electron Microscopy (SEM), thermogravimetry (TG) and Differential Exploration Calorimetry (DSC) were analysed. The nanoparticle system was evaluated taking into consideration particle stability prior and posterior to the addition of the extract, as well as coated and uncoated particles. The results demonstrated the good reactivity of the monomers of cyanoacrylates, as well as effectiveness of hyaluronic acid in relation to the proposed objective, evidenced in the results obtained by Infrared Spectroscopy, by SEM, DSC and, also, TG. The study demonstrated that there are possible future applications for this method.

brazilian journal of natural sciences

Polymeric nanoparticles containing Tithonia diversifolia (hemsl) a. Gray flowers alcoholic extract and coated by hyaluronic acid_ development, synthesis, and characterization