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Gelatin–Cloisite 30B (C 30B) hybrid nano-composites were prepared by blending gelatin with cloisite 30B in aqueous solution. The nano-composites were characterized by using FTIR, SEM and XRD analysis. From the FTIR spectra the various groups present in the gelatin blend were monitored. The homogeneity, morphology and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The results indicate that an intercalated or partially exfoliated nano-composite can be achieved, and the properties of the composite are significantly improved. The drug release kinetics was investigated using ofloxacin as the drug. The kinetics of the drug delivery system was systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data vs. time by fitting to an exponential equation which indicates the non-Fickian type of kinetics. The drug release was investigated at different pH medium and it was found that the drug release depends upon the pH medium as well as the nature of the matrix.

Controlled release of ofloxacin from gelatin blended with cloisite 30B