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Sensitive and simple spectrofluorometric method has been developed and validated for the quantification of sulpiride in pure, commercial formulations, human plasma and urine in the presence of sodium dodecyl sulphate (SDS) surfactant micelle. The experimental parameters like buffer, surfactant type and volume were studied. A linear relationship was found between sulpiride concentration and fluorescence intensity in the range of 0.02 μg mL –1 –7.0 μg mL –1  containing 0.2 M sodium dodecyl sulphate with λ ex  292 nm and λ em  343 nm with a correlation coefficient of 0.9987. The limit of detection (LOD) and limit of quantification (LOQ) was found to be 1.9 × 10 –2  μg mL –1  and 5.9 × 10 –2  μg mL –1  respectively. The proposed method was successfully applied for the determination of sulphiride in pure and dosage form; the percentage recoveries agreed well with the label value. The effect of common excipients used as additive in pharmaceutical formulations was studied and no interferences was found. Similarly the effect of some common cations and compounds present in urine and plasma were also investigated and the method was found free of interferences. The method was further extended to the in-vitro determination of sulphiride in spiked human plasma and urine samples with percentage recoveries from 98.33%–99.75% and 95.67%–101.67% respectively. The results of the proposed method have been compared with the literature HPLC method and no significant difference was found between them.

tenside surfactants detergents

Development and Validation of Micellar-Enhanced Spectrofluorimetric Method for Determination of Sulpiride in Pharmaceutical Formulations and Biological Samples