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As clouding in drugs causes high concentration of drug at a particular site which may prove harmful to the body, the clouding behaviour of a tricyclic phenothiazine drug promazine hydrochloride (PMZ) in aqueous solutions has been studied in the presence of surfactants and ureas. The cloud point (CP) decreases with increase in pH due to deprotonation of the drug molecules. Addition of non-ionic and cationic (conventional as well as Gemini) surfactants increased the CP whereas anionic surfactants showed a peaked profile. The urea family additives influenced the CP in both ways that depended whether they contain &gt;C=O or &gt;C=S moiety: the former interacts with the micelles and lowers the CP while the latter (due to its electropositive character) may not interact and hence CP increases. Dye solubilization results indicate micellar growth with the addition of surfactants in PMZ solutions. The results are interpreted taking cognizance of mixed micelle formation, hydrophobic interactions, and/or change in solvent structure.

Phase Separation Study of a Surface-Active Drug, Promazine Hydrochloride, in Presence of Surfactants and Ureas