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The anti-inflammatory effects of two phlorotannins identified in the brown alga Eisenia arborea, i.e., 6,6′-bieckol and 6,8′-bieckol, were previously determined in vitro. Here we investigated the in vivo effects of these phlorotannins in mice. In ICR mice, ear swelling was induced by three sensitizers: arachidonic acid, 12-O-tetradecanoylphorbol13-acetate (TPA) and oxazolone (OXA). Swelling was suppressed after the two phlorotannins were applied to the mouse ears. In particular, compared with epigallocatechin gallate, a typical natural inhibitor, the phlorotannins had a significantly greater effect on OXA-induced ear swelling (6,6′-bieckol, p < 0.05; 6,8′-bieckol, p < 0.01). This is the first report to confirm the anti-inflammatory effects of 6,6′-bieckol and 6,8′-bieckol in vivo.

Anti-inflammatory Effects of 6,6′-bieckol and 6,8′-bieckol from <i>Eisenia arborea</i> on Mouse Ear Swelling