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*To whom correspondence should be addressed. E-mail: Yamamoto@tokaigakuen-u.ac.jp Introduction The pathogenesis of a wide range of lifestyle diseases such as hypertension and cardiovascular disease is not fully understood. However, the role of oxidative stress on the genesis and maintenance of these diseases has been revealed in experiments involving administration of several types of antioxidants, with a consequent lowering of the risk of these diseases (Rodríguez et al., 2002; Vasdev et al., 2001; Chen et al., 2001; Schnackenberg and Wilcox, 1999). Oxidative stress initiated by reactive oxygen species (ROS) might be a factor in these pathological conditions via oxidation of biological macromolecules such as lipids, protein, and DNA. Thus, there is growing interest in the many antioxidative components in foods for the prevention of ROS-induced oxidative damage. Flavonoids are widely distributed in many kinds of plant food sources. The beneficial effects of flavonoids on human health have been widely studied, and antioxidative activity was proposed as one of the most important causes of these effects (Duarte et al., 1993; Duarte et al., 2001; Yamamoto and Oue, 2006; Gryglewski et al., 1987; Yu et al., 2006; Villar et al., 2002). Quercetin is the most abundant flavonol type of flavonoid, and a wide range of biological actions including vasodilation, antihypertensive, and antithrombotic effects have been reported (Duarte et al., 1993; Duarte et al., 2001; Yamamoto and Oue, 2006). Chrysin is a flavone-type flavonoid, and is present in foods like honey and propolis, and in many kinds of fruits and vegetables at low concentrations. Additionally, chrysin is commercially available as an androgen-boosting supplement (Kao et al., 1998). Previous experiments have suggested that chrysin possesses in vitro antioxidative and free radical scavenging activities (Rackova et al., Original paper

Effects of Dietary Chrysin Supplementation on Blood Pressure and Oxidative Status of Rats Fed a High-Fat High-Sucrose Diet