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Penicillins are one of the most often used group of antibiotics. They are bactericidal antibiotics of high effectiveness against infections caused by numerous pathogens. Introduction of semisynthetic penicillins additionally widened the spectrum of their usage and raised their effectiveness. Although, it is a relatively safe group of medicines, there are some hypersensitivity reactions. However, penicillins still remain first-line antibiotics. Therefore self-reported allergic reactions each time should be confirmed by a detailed allergological diagnostics. Restrictions of prescribing penicillins due to an unproven allergy reaction leads to increasing drug resistance, as well as to increased cost of treatment.

The role of penicillins in antibiotic treatment – effectiveness and safety of use of ‘old antibiotics’