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The effect of “Mosque Lifesaver Training” on lay persons’ knowledge and willingness to perform basic life support in Indonesia Ahmad Jamaluddin,1,2 Sheli Azalea,1,3,4 Rizki Andita Noviar,1,7 Dian Eka Putra Suwarto,1 Nyityasmono Tri Nugroho,1,5,6 Abstract: Background: Cardiac arrest mostly happens in out hospital setting. Bystander CPR improves survival after out-of-hospital cardiac arrest.In 2018 BSMI Jakarta Raya started the Mosque lifesaver training as basic life support training for laypersons’ in Indonesia, optimizing mosques as the center of community activities. The aim of this study is to evaluate the effect of “mosque lifesaver training” for the laypersons’ knowledge and willingness to perform basic life support. Methods: There are 247 people from twelve mosques that participated in this research. The participants were given fifteen multiple-choice preposttest questioners in basic life support knowledge, one full day two-direction training, one-by-one practicing in small group for adult and pediatric CPR (Cardio-Pulmonary Resuscitation), and CPR skill test. Data was collected and statistically analyzed with SPSS 24 Software by IBM. Results and discussion: From 247 participants, 32 were excluded due to lack of data. For rest of 215 participants, 32.1% was housewife, mean value of age was 39.1 ± 0.9 SD years, educational background was bachelor in 44.7% participants. Mean value of pre-test and post-test were 28.70 ± 16.8 SD and 55.73 ± 19.30 SD, respectively. The post-test result has significant correlation of profession (p=0.003), but no significant correlation of age (p=0.08) and educational background (0.51). Marginal homogeneity test for pre and post test data brought p<0.001 significance. Before the training, only 57.2% participants had willingness to perform cardiopulmonary resuscitation. After the training, 91.2% participants have willingness to perform cardiopulmonary resuscitation if witness sudden cardiac arrest of unknown people. Conclusion: Participants who enrolled the training were predominantly by housewife, productive age with bachelor educational background. Mosque lifesaver training show significant improvement in laypersons’ knowledge and willingness to perform basic life support.