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The demand for pork and poultry products is strongly influenced by the consumers concern for healthy and safe food. The topic of food safety mainly concentrates on Salmonella contamination and is recently joined by the topic of antimicrobial resistance due to the use of antimicrobial growth promoters (AGP) in animal feed. Recent research findings on Flavomycin (flavophospholipol), registered as an AGP for pigs, poultry and cattle, describe a reducing effect on the development of antibiotic resistance and on the frequency of plasmid transfer. Flavophospholipol does not induce an antibiotic resistance to antibiotics used for veterinary or human therapy as it is not related to any antibiotic used for these purposes. Furthermore, it is capable of reducing antibiotic resistance to other antibiotics. This effect seems to be yielded by interfering in the biosynthesis of the plasmid bridge (pylus) which is a prerequisite for the genetic transfer from one bacteria to another. Introduction The demand for pork and poultry products is strongly influenced by the consumers concern for healthy and safe food. The topic of food safety mainly concentrates on Salmonella contamination and is recently joined by the topic of antimicrobial resistance due to the use of antimicrobial growth promoters (AGP) in animal feed. Latest findings on flavophospholipol, registered as AGP for pigs, poultry and several other species, describe a reducing effect on the development of antibiotic resistance and on the frequency of plasmid transfer. Methods For the first investigation, conducted at the University of Maastricht (The Netherlands) by van den Boogard (2002), 168 piglets were infected per oral administration with non-pathogenic E. coli strains, with a known multi resistance pattern. Four weeks later the animal’s feces were analyzed for the occurrence of E. coli and vancomycin resistant enterococci (VRE). Furthermore the isolated E. coli strains were tested for their sensitivity to various antibiotics (ampicillin, oxytetracycline, trimethoprime, sulphamethoxazole, ampicillin + oxytetracycline). After that the piglets were divided into three groups. Feed of group I served as control, feed of group II was supplemented with 9ppm Flavomycin and the feed for group III was supplemented with 15ppm avoparcin. Just before being slaughtered animals feces was analyzed again in the Human therapy Veterinary therapy AGP Lincosamides x x lincomycin Nitrofurans x x Furox, nitrofurazone

Reduction of antimicrobial resistance as induced by Flavomycin