English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Meticillin-resistant Staphylococcus aureus (MRSA) ST398 has not been detected in pigs in Ireland. However, other strains of MRSA, including MRSA t002, have been isolated from animals and humans in Ireland. The aim of this study was to determine if nasal colonization of pigs with a non-ST398 strain of MRSA could be reproduced using intra-nasal inoculation and to investigate subsequent transmission of this strain. Six pigs were inoculated intra-nasally with 2 x 109cfu MRSA t002. Six days post-inoculation these pigs were washed and moved to a clean house with 15 unexposed pigs (In-contact group). Another 15 unexposed pigs were added to the vacated house (Environment group). The inoculated pigs and Incontact group were moved to a clean house every 2 days to minimise exposure to MRSA in the environment. Nasal swabs were taken for MRSA culture from all pigs and counts were undertaken from samples from inoculated pigs. Inoculated pigs were euthanized 5 weeks post-inoculation and exposed pigs were euthanized 4 weeks post-exposure to MRSA. Upper respiratory tract samples were taken at postmortem for MRSA culture. All inoculated pigs were MRSA-positive for 5 days post-inoculation. Thereafter the number of positive pigs decreased with no inoculated pig positive after 17 days post inoculation. However, MRSA was isolated from three inoculated pigs following postmortem culture. Ten of the 15 pigs from the Environment group were MRSA-positive during the first 3 days post-exposure but all 15 were negative on subsequent samplings. Only 3 of 15 pigs in the In-contact group were MRSA positive during the first 3 days post-exposure; 4 other pigs in this group were MRSA-positive on subsequent samplings. This study demonstrates that, experimentally, pigs can become colonised with a non-ST398 strain of MRSA which can be transmitted by both direct contact with colonised pigs and by environmental exposure alone. However, transmission by both routes appeared to be inefficient and risk of persistence was low under these conditions.

Investigation of MRSA transmission between pigs and the environment following intra-nasal inoculation