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iv Introduction 1 Materials and Methods 6 Results 11 Discussion 38 Appendix A. The known TNF superfamily members from different species 41 Appendix B. PSI-BLAST and HMM results of known human TNFs and C-1-Q proteins 51 Appendix C. Sequences of the potential TNF-like hits in human and Arabidopsis genomes recognized by the protein structure threading scheme 53 References 54 Acknowledgements 58

Genome wide recognition of tumor necrosis factor (TNF) like ligands in human and Arabidopsis genomes: a structural genomics approach