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Guinea pigs were given cyclopiazonic acid (CPA) at 4 mg/kg/day for 3 or 4 days. Guinea pigs were killed 24 hours after receiving the last dose of CPA and muscles were examined by histochemistry, and light and electron microscopy. Degeneration and necrosis with decreasing severity were in gastrocnemius, biceps femoris, vastus lateralis, and diaphragm. The soleus had rare, swollen eosinophilic fibers, but no necrotic fibers. Degenerate fibers had dilated sarcoplasmic reticulum, mild loss of myofilaments and Z-lines, and swollen mitochondria with expanded, more lucent matrices and occasional dense matrix granules. More severely affected myofibers had condensed clumps of myofilament debris, swollen mitochondria with dense granules and disorganized cristae, swollen sarcoplasmic reticulum, and focal loss of plasmalemma. Creatine phosphokinase (CPK), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, and phosphorus were all increased in serum from guinea pigs given CPA. Amounts of vitamin E and selenium in liver were similar in CPA-treated guinea pigs and controls.

Ultrastructure, histology, and histochemistry of an acute myopathy in guinea pigs given cyclopiazonic acid