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iv GENERAL INTRODUCTION 1 Thesis Organization 1 Literature Review 1 Fatty acids and health 1 Factors affecting beef fatty acid composition 3 Regulation of fatty acid synthesis 9 CHAPTER 1. DNA POLYMORPHISMS IN BOVINE FATTY ACID SYNTHASE ARE ASSOCIATED WITH BEEF FATTY ACID COMPOSITION 24 Summary 25 Introduction 26 Materials and Methods 27 Results 31 Discussions 36 References 39 Tables 43 Figures 53 CHAPTER 2. ASSOCIATION OF POLYMORPHISM IN THE PROMOTER I OF BOVINE ACETYL-COA CARBOXYLASE-α GENE WITH BEEF LIPID CONTENT 55 Summary 56 Introduction 56 Materials and Methods 57 Results and Discussions 60 References 63 Tables 66

Genetic regulation of the healthfulness of beef fatty acid composition