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105 Keyword Index 106 Introduction 106 Results/Discussion 108 Conclusions and Concluding Remarks 117 Experimental 117 Acknowledgements 122 Literature Cited 123 Tables 127 Figure Legends 131 Figures 133 CHAPTER 5. IDENTIFICATION OF PATHWAYS IMPORTANT FOR THE ANTI-INFLAMMATORY ACTIVITY OF AN HYPERICUM PERFORATUM FRACTION AND FOUR PUTATIVE BIOACTIVE CONSTITUENTS IN RAW 264.7 MOUSE MACROPHAGES USING MICROARRAY ANALYSIS 138 Abstract 138

Elucidation of anti-inflammatory constituents in Hypericum perforatum extracts and delineation of mechanisms of anti-inflammatory activity in RAW 264.7 mouse macrophages