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iv CHAPTER 1: GENERAL INTRODUCTION 1 Thesis Organization 3 References 5 CHAPTER 2: A MODEL FOR LIGAND BINDING TO HEXACOORDINATE HEMOGLOBINS 7 Abstract 7 Introduction 8 Materials and Methods 9 Results 12 Discussion 20 Acknowledgements 24 References 25 CHAPTER 3: HUMAN NEUROGLOBIN, A HEXACOORDINATE HEMOGLOBIN THAT REVERSIBLY BINDS OXYGEN 36 Abstract 36 Introduction 37 Materials and Methods 39 Results 42 Discussion 44 Acknowledgements 48 References 49 CHAPTER 4: A UBIQUITOUSLY EXPRESSED HUMAN HEXACOORDINATE HEMOGLOBIN 56 Abstract 56 Introduction 57 Materials and Methods 58 Results 62 Discussion 67 Acknowledgements 73 References 74 CHAPTER 5: CRYSTALLOGRAPHIC ANALYSIS OF SYNECHOCYSTIS CYANOGLOBIN REVEALS THE STRUCTURAL CHANGES ACCOMPANYING LIGAND BINDING IN A HEXACOORDINATE HEMOGLOBIN 89 Abstract 89 Introduction 90 Results 91

An examination of hexacoordinate hemoglobins using the techniques of biochemistry, biophysics and molecular biology