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Three studies are described in this report. In the first study, the effects of danofloxacin and tilmicosin on neutrophil function were examined in healthy mixed-breed weaned beef heifers. Neutrophils were isolated from peripheral blood samples preand posttreatment. The neutrophil flmction assays performed were: random migration under agarose. Cytochrome C reduction, iodination. Staphylococcus aureus ingestioi., chemotaxis under agarose, and antibody-independent and antibody-dependent cell-mediated cytotoxicity. The results suggest that at therapeutic drug concentrations, danofloxacin and tilmicosin have little clinical effect on bovine neutrophil function. In the second study, a model was developed for the induction of pneumonic pasteurellosis (using 6 x lO' CFU of a log-phase culture of Pasteurella haemolytica intrabronchially) in weaned, pre-conditioned beef calves that consistently produced rectal temperatures of at least 40°C 24 hours after bacterial challenge, a clinical score of >1, and measurable lung consolidation. In the third study, Pasteurella pneumonia was induced in weaned beef heifer calves using the model from the second study, and calves were treated with danofloxacin or tilmicosin. Neutrophils were collected at 3,24 and 48 hours after treatment. Neutrophil function assays were as performed in study 1, and apoptosis was determined using a cell death detection kit. The results suggest that danofloxacin and tilmicosin have no clinically significant effects on neutrophil function or apoptosis. There were also no significant differences in percent lung consolidation among treatments. Significant differences were found between non-challenged calves and the challenged non-treated calves in several neutrophil assays, which were attributed to an effect of the Pasteurella infection. Body temperature was also examined in this study via intravaginally implanted radiotransmitters. Temperatures were monitored prior to challenge

The effects of danofloxacin and tilmicosin on peripheral neutrophils in healthy cattle, on peripheral neutrophils in cattle with induced Pasteurella haemolytica pneumonia, and on body temperature measured via radiotelemetry in cattle with induced Pasteurella haemolytica pneumonia