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Early-weaned pigs (n=64) averaging 5.3 ± .3 kg and distributed into two environments (dirty and clean) were used to evaluate effects of CLA on growth performance, immune competence and empty body composition. A factorial (2 design with four littermate pigs as the experimental unit for the environment, pig within litter as the experimental unit for dietarv' treatment, and d 0 body weight used as a covariate were used in data analysis. Diets were formulated to contain CLA at 0. .67. 1.33 or 2% and to exceed NRC (1988) nutrient needs of pigs, and were self-fed for 7 wk in three phases (I. I to 2: II. 3 to 5: and III. 6 to 7 wk). Within phases, diets were isocaloric and isonitrogenous. In phase I as CLA concentration increased. ADFI decreased (P increased quadratically (603. 623.622. and 548 g/d: P 840. 867. and 717 g/d; P P treatments. Pigs in the clean room had a greater cumulative ADG (P<.01) and a greater ADFI

Dietary conjugated linoleic acid expands CD8+ lymphocyte subsets in vivo and enhances their function