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CHAPTER I. GENERAL INTRODUCTION 1 Dissertation Organization 1 Research Objectives 1 Background and Literature Review 2 CHAPTER II. CO-EXISTENCE OF a,-ADRENOCEPTOR SUBTYPES IN THE BOVINE TAIL ARTERY. 38 Abstract 38 Introduction 39 Materials and Methods 41 Results 45 Discussion 46 Acknowledgments 48 References 48 CHAPTER III. CHARACTERIZATION OF a,aAND a,b-ADRENOCEPTOR SUBTYPES IN THE BOVINE TAIL VEIN 66 Abstract 66 Introduction 67 Materials and Methods 69 Results 73 Discussion 74 Acknowledgments 77 References 77

Characterization of [alpha]-adrenoceptor-mediated contractile responses in the isolated bovine tail artery and vein and an investigation of nerve-mediated contraction in the bovine tail artery in response to electrical field stimulation