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8 INTRODUCTION 9 MATERIALS AND METHODS 12 RESULTS 19 DISCUSSION 48 REFERENCES 53 SECTION II: A NORMAL MITOCHONDRIAL PROTEIN IS SELECTIVELY SYNTHESIZED AND ACCUMULATED DURING HEAT SHOCK IN Tetr ahymeria thermophi la 57 ABSTRACT 58 INTRODUCTION 59 MATERIALS AND METHODS 62 RESULTS 70 DISCUSSION 98 REFERENCES 10358 INTRODUCTION 59 MATERIALS AND METHODS 62 RESULTS 70 DISCUSSION 98 REFERENCES 103 SECTION III: IDENTIFICATION OF A HIGHLY EVOLUTIONARILY CONSERVED MITOCHONDRIAL PROTEIN WHICH IS STRUCTURALLY RELATED TO THE PRODUCT OF THE E. coli groEL GENE 109 ABSTRACT 110

The metabolism and localization of two proteins during heat shock of Tetrahymena thermophila