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The present study was conducted to determine whether increasing dietary linoleate and vitamin E supplementation interact to maintain a relatively andthrombogenic rado of thromboxane : prostacyclin. The influence of increasing dietary linoleate and d,l-a-tocopheryl acetate (vitamin E) on platelet fatty acid composition, phospholipase A2 activity, lipid peroxidation, serum thromboxane B2 (TXB2), 6-keto-prostaglandin Fia (6keto-PGFia) and aortic o-keto-PGFia concentrations was studied in 72 weanling male Sprague-Dawley rats. Rats were fed semipurified diets containing 11 or 18% of energy from linoleate (en% linoleate) and graded levels (0,100 or 5000 ppm) of vitamin E for 10 weeks. Vitamin E status was confirmed by platelet vitamin E level. Rats fed no vitamin E had the lowest platelet vitamin E and rats fed 5000 ppm vitamin E had the greatest platelet vitamin E (p<0.05). Lipid status was verified by platelet fatty acid composition. Platelet C18:ln-9 (oleic acid) was significantly greater in the 11 en% linoleate group than in the 18 en% linoleate group, and platelet C18:2n-6 (linoleic acid) was significantiy greater in the 18 en% linoleate group than in the 11 en% linoleate group (p<0.05). Increasing dietai'y linoleate from 11 to 18 en% had no adverse effect on thrombogenic potential as reflected in serum TXB2/6-keto-PGFia ratio. Serum TXB2 level and platelet lipid peroxidation (TBARS) were significantly greater in the vitamin E-deficient group than in other groups (p<0.05). Vitamin E supplementation had no protective effect on tiirombosis based on serum TXB2/6-keto-PGFia ratio. There was no interaction between increasing dietary linoleate and vitamin E supplementation on thrombogenic potential, as reflected by eicosanoid status,

Effects of fat saturation and vitamin E on fatty acid and vitamin E status in platelets and prostaglandins and cholesterol concentrations in serum