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Purpose: To characterize the pupil light reflex (PLR), electroretinographic (ERG) and tonometric parameters in healthy rat eyes. Methods: Brown Norway rats were used for experiments. The PLR was evaluated with a computerized pupillomotor (n=27), ERGs were recorded simultaneously from both eyes (n=27) and IOP was measured with a Tonopen (n=15). Results: The analysis of the PLR parameters confirmed the consensual PLR was significantly smaller in amplitude (p=0.03) and increased latency time (p=0.001 ) compared to the direct PLR. Electroretinography (1600+200 cd/m2) revealed a-wave amplitude of 207.2+13 jiV and the b-wave 554.3+24.5 |iV. The flicker ERG recording revealed amplitudes of 40.6+2.4 fiV. Tonometry measurements revealed that isoflurane, but not halothane, anesthesia suppressed the IOP (non-anesthetized: 25.3+1.0 mmHg; 1% halothane+30% NO: 26.2+1.1 (p>0.05); 1% isoflurane+30% NO: 20.1+1.6 (p<0.05)). Conclusions: Consensual PLR in rats has a relative deficit comparing to the direct PLR. Isoflurane anesthesia has suppressive effect on the IOP in healthy rat eyes.

Functional characterization of retina and optic nerve after acute and chronic elevation of the intraocular pressure in rats