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The mitogen-regulated protein/proliferin {mrp/ptf) genes belong to the prolactin/growth hormone gene superfamily and encode at least four closely related proteins. Identified functions of these proteins include stimulation of uterine proliferation and endothelial angiogenesis. In 3T3 cells, basic fibroblast growth factor (bFGF) stimulates the production of mAp/p/ mRNAs with a resulting increase in the protein products. Although the three cloned mqj/plf gene promoters {mrp3, ptf42, and plf149) are over 97% identical in sequence, only mrp3 is transcriptionally activated by bFGF. We have identified a sequence in the mrp3 promoter, which we have named the "bFGF-responsive element" (FRE), that specifically binds nuclear factors from 3T3 cells. Analysis of the bFGF-responsiveness of a series of truncated mrp3 promoter sequences combined with footprint analysis, pinpointed a region of the promoter that contains a large variation in sequence between the three promoters and one base in the sequence that is unique to the mrp3. The nuclear factors bound by the FRE are present in the placenta and the fetus in which the ^Department of Biochemistry, Biophysics and Molecular Biology and the Molecular, Cellular, and Developmental Biology Program. Iowa State University. Ames, lA 50011 ^Currently Research Fellow in Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129

Investigating the mechanism of mrp/plf gene expression by bFGF