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and Implications The differences between relatively resistant and susceptible chicken lines can be utilized to study the genetics behind disease resistance. To assess resistance, the viral quantity in each bird was measured after challenge with Newcastle Disease Virus (NDV) at two time points. As predicted, the resistant line was able to clear the virus more quickly than the susceptible line. Further studies are needed to determine the genetics responsible for resistance. Introduction Newcastle Disease Virus (NDV) is a devastating disease that results in high mortality of unvaccinated chickens. In the United States, NDV can cause losses in egg production and respiratory problems, but this is generally prevented by vaccination. In developing countries, the protein and monetary value that families receive from chickens are crucial to their survival. In these countries where the vaccine is not availble due to poor infrastructure and economic restraints, finding sustainable approaches to combat NDV is vital. Utilizing traditional breeding approaches to select for chickens more resistant to the virus is a viable solution. To aid in this goal, we will search for the underlying genetic control of resistance. Our approach involves the use of two inbred chicken lines that have been shown to be relatively resistant (Fayoumi) and susceptible (Leghorn) to many avian pathogens. If these birds differ in their resistance to NDV, we expect the resistant Fayoumi's immune system to allow less viral replication and have a lower viral load than the susceptible Leghorn.

Do Two Distinct Chicken Lines Differ in Their Response to Newcastle Disease Virus?