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Psoralen ultraviolet A (PUVA) is a proven modality in dermatological therapeutics. It is widely practiced in the treatment of psoriasis, vitiligo, atopic eczema, certain skin cancers, photosensitivity dermatoses, alopecia areata, graft-versus-host disease and morphea.1-3 In presence of UVA, psoralen intercalates between the DNA base pairs forming functional adducts, free radicals and reactive oxygen species thus causing cross linking of DNA strands, protein conjugation and cytotoxic effects.

Practical Aspects in Topical PUVAsol in Dermatology: An Experience in a Teaching Hospital