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Oral submucous fibrosis (OSF), a potentially malignant oral lesion, is a form of pathological fibrosis affecting the oral mucosa. It results from an imbalance in equilibrium of the normal process of synthesis and degradation of extra cellular matrix. Matrix metalloproteinases and its inhibitors play important role in remodeling of the extra cellular matrix which are important in progression and pathogenesis of potentially malignant lesions to malignancy.

kathmandu university medical journal

Evaluation of Matrix Metalloproteinases-2 (MMP-2) and Tissue Inhibitors of Metalloproteinases-2 (TIMP-2) in Oral Submucous Fibrosis and Their Correlation With Disease Severity