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Benzylpenicillin, also known as (3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic, is a common bactericidal antibiotic of the betalactamin family which is mostly used to treat infections caused by gram-positive bacterial strains and few gram-negative bacterial strains. Cr (III) complex of benzylpenicillin was synthesized by the reaction of benzylpenicillin with CrCl3.6H2O. The structure of the complex was confirmed through elemental analysis, electrical conductivity, FT-IR, electronic spectra, 1H-NMR, and 13C-NMR spectroscopic methods. The physical properties such as solubility, color and melting point were also determined for both the ligand and the complex. The complex has a deep green color. Both the ligand and the complex are ionic (236.0 and 126.0 Sm2.mol-1). From the spectroscopic result, the ligand behaved as a pentadentate ligand coordinating to the metal ion through OH, NH, C=O of amide, carboxylate& β-lactam. A trigonal bipyramidal geometry has been proposed for the metal complex. The prepared complex was evaluated in vitro for its antibacterial activity against some pathogenic gram-positive (Staphylococcus aureus, Bacillus substilis, Bacillus cereus, and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli, Enterobacter cloacae, Pseudomonas aeruginosa and Campylobacter fetus). The metal complex showed enhanced antibacterial activity as compared to the uncomplexed ligand.

Synthesis, Characterization and Antibacterial Studies of (3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid-Cr (III) Complex