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Background: Diabetes mellitus, a worldwide health problem, is associated with increased oxidative stress and reduced antioxidant defense in the body. The role of hydrogen sulfide and the H 2 S synthesizing enzymes in relation to type2 diabetes is a recently unveiled field which needs further research work. Aims and Objectives: Aim of the study was find out the relationship of plasma H 2 S levels and H 2 S synthesizing activity in plasma with oxidative stress conditions in the patients suffering from type-2 diabetes mellitus. Materials and Methods: Sixty two patients suffering from type2 diabetes as well as similar number of healthy volunteers were enrolled for the study. Plasma H 2 S levels and H 2 S synthesizing activity in plasma as well as total oxidative stress and total antioxidant levels were measured by earlier methods already published from our laboratory. Results: The values of FBG, PPBG, HbA 1C , fasting Insulin, plasma H 2 S and H 2 S synthesizing activity in plasma and TOS values in patients are significantly higher (p < 0.05) than the corresponding values in healthy controls. The median and inter quartile range of TAD values in controls is significantly higher than those of the patients (Mann Whitney U, Z<0.001). Plasma H 2 S levels show significant positive correlation with TOS values (r= 0.793, P<0.001), and significant negative correlation with TAD values (r= -0.753, P<0.001). Conclusion: The current study elucidated that there is significant increase in both plasma H 2 S levels and the activity of H 2 S synthesizing enzymes in type2 diabetics and well correlated with the total oxidative stress and antioxidant defense. Asian Journal of Medical Sciences Vol.7(5) 2016 22-30

Increased plasma H2S levels well correlated with total oxidative stress and total antioxidant defense in type2 diabetes patients.