English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: The emergence of parasite resistance to artemisinins typified by slower parasite clearance rates in some parts of South east Asia has necessitated the search for alternatives. Objective: This study evaluated the in vitro and in vivo antimalarial activity and the cytotoxicity profile of the nhexane, dichloromethane and methanol extracts of Garcinia kola seeds. Methods: In vitro susceptibility of chloroquine-sensitive PF D10 strain to the extracts was evaluated using parasite lactate dehydrogenase assay while cytotoxicity was determined using 3-[4,5-Dimethylthiazol-2-yl]-2,5diphenyltetrazolium bromide (MTT) assay with Vero cells and emetine as standard drug. Chloroquine-resistant P. berghei (ANKA) infected Swiss mice allotted into 14 groups of 5 per group: corn oil (5mL/kg), 50, 100, 200, 400 mg/kg of each extract and chloroquine (10 mg/kg) were used to evaluate in vivo antimalarial activity in a 4-day suppressive test. Results: The n-hexane, dichloromethane and methanol extracts of the seeds of Garcinia kola were active in vitro against chloroquine sensitive P. falciparum D10 strain with IC50 values ≤ 26 μg/mL. The hexane and dichloromethane extracts were noncytotoxic against Vero cells with IC50 values ≥ 27 μg/ml The hexane extract of Garcinia kola seeds reduced parasitemia by 70% at 400 mg/kg and prolonged survival in mice infected with P. berghei ANKA. Conclusion: The observed antimalarial activity justifies the use of Garcinia kola seeds in the treatment of febrile illnesses.

Antimalarial Activity and cytotoxicity profile of the seed extracts of Garcinia kola (GUTTIFERAE)