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Phytochemical studies on the stem bark of Canthium subcordatum afforded eight known compounds: βsitosterol (1), ursolic acid (2), cerbinal (3), quinovic acid (4), Cerberinic acid (5), 3-O-β-Dglucopyranosylquinovic acid (6), 3-O-β-D-glucopyranosyloleanolic acid (7) and Clemahexapetoside B (8). Interestingly, 3, 5 and 8 were isolated and characterized for the first time from the genus Canthium. Their structures were elucidated using their physical and spectroscopic data. Furthermore, antiplasmodial potency of Canthium subcordatum and antimicrobial activities of 6, 5 and 8 has not yet been investigated. Fractions and isolates were tested for their antiplasmodial potency. Only the methanol fraction inhibited the growth of P. falciparum with an IC50 value of 3.044 μg/mL. The isolates were also tested against eight bacteria and fungi strains. 4 and 5 were the most active with inhibition diameter zones equal or above 12 mm and MIC equal or lower than 39 μg/mL.

Antiplasmodial and antimicrobial potential of Canthium subcordatum extracts and isolates