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The ripe fruits of C. metuliferus were collected in Vom village, Jos South Local Government Area, Plateau State, Nigeria. The fruits were washed and sliced using clean knives, and then air dried in the laboratory and pulverized. The dried powder was serially extracted using solvents of different polarities (n-hexane, chloroform, methanol and distilled water). The biochemical research involving animals was carried out according to the principles of Council for International Organizations for Medical Science (CIOMS) and the International Council for Laboratory Animal Science (ICLAS), 2012 and was approved by the Ethics Committee, Faculty of Veterinary Medicine, University of Maiduguri, Borno State, Nigeria. Twenty, 7-week old cockerels were used for this study. They were randomly divided into four groups of 5 chicken each (groups A, B, C and D). Cockerels in group D served as the untreated control and were given only feed and distilled water daily for a period of 28 days. The cockerels in groups A, B and C were treated daily orally with graded doses of the most active of the fruit extracts, that is crude methanol extract (CME), (200, 400 and 600 mgkg respectively). Haematological effect of the prolonged administration of the extract was examined in cockerels. Birds treated with 200, 400 and 600 mg/kg of the extract exhibited significant (p<0.05) increase in PCV, Hb and RBC count on day 14 and 21 after treatment. There was a significant (p<0.05) decrease of MCV and MCH throughout the periods of experiment of the treated groups, while MCHC significantly (p<0.05) decrease after 7 days post-treatment.

Effects of crude methanol extract of the fruit of Cucumis metuliferus (Cucurbitaceae) on some haematological parameters in Cockerels