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Introduction: Lifestyle and a variety of factors and conditions as well as genetics can cause damage to the liver, such as viruses and alcohol use which leads to end stage liver disease. Liver disorders be it inherited or due to lifestyle ranges from benign lesions and scarring (cirrhosis) to liver cancer. A retrospective review of post mortem cases with liver disorders in our center will give a clear picture of the trend and spectrum of such disorders to aid in review of clinical prognosis when dealing with patients. Methods: Information on cause of death as well as demographics were retrieved from the Autopsy Day Book of the department of pathology, Komfo Anokye Teaching Hospital where the clinical diagnoses, pathological findings and other relevant data were gathered. The data was entered into Microsoft Excel and analyzed using SPSS version 22. Results: Findings from the 445 autopsy cases revealed a total of ten (10) different diagnoses with some major disorders as well as complications. Males accounted for the most cases with 324 (72.81%) of cases with 121 (27.19%) for women. Liver cirrhosis accounted for more than half of all diagnoses made with 257 (57.75%) of cases, followed by liver cancer with 97(21.80%) of cases and both hepatic encephalopathy and hepatorenal disease recording a case each (0.22%). The age range is from 8 months to as high as 102 years with the 30-39 years group recording the highest number of cases, 124 (27.86%) and both the extremes of age groups recording the least with 7 (1.57%) each. Most of the cases recorded clustered around the middle age group with particularly high cases for ages 30 to 49. Conclusion: Liver cirrhosis is the commonest liver disorder in our center and young men are at more risk for liver diseases. Most of these liver complications are also more frequently overlooked by clinicians since they are usually asymptomatic.

Spectrum of Liver Disorders and Mortality at a Tertiary Hospital; A 7-Year Retrospective Post mortem Study