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Aims: Type 2 diabetes mellitus (T2DM) is associated with great disease burden since it has high prevalence, morbidity and mortality rates. Platelets (PLT) are directly or indirectly involve in the processes of chronic complications in T2DM. Beside serving as a marker of platelet activation, mean platelet volume (MPV) is also considered as an inflammatory indice. A MPV to PLT ratio (MPR) is introduced as a novel inflammatory predictor and a marker of worse outcome, recently. We aimed to study MPR levels of type 2 diabetic patients in present report. Methods: Subjects older than 18 years old and with type 2 diabetes mellitus treated in outpatient internal medicine clinics of our university hospital during June 2017 to December 2017 were included. Medical data of the patients obtained from computerized database of the institution analyzed retrospectively. General characteristics and laboratory parameters of the participants, were compared to those in healthy controls. Results: We found significantly increased MPR in diabetic subjects compared to healthy volunteers (p=0.02). Moreover, MPR and fasting blood glucose (r=0.264, p<0.001), and MPR and HbA1c (r=0.234, p=0.003) were significantly and positively correlated (r=0.234, p=0.003). Conclusion: We suggest that, elevated MPR in otherwise healthy subject should courage physicians for prompt evaluation for type 2 DM. Correlations between MPR and fasting plasma glucose and HbA1c need validation with further studies with larger population.

Is Mean Platelet Volume to Platelet ratio a promising indicator of diabetic regulation in type 2 diabetes mellitus?