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Pernicious anemia (PA) is widely distributed a public health problem with sever life threatening complications. Deficiency of vitamin B12 is the main cause of it. The chronic infection with Helicobacter pylori (H. pylori) is one of the causative agents of both vitamin B12 deficiency and thereby development of PA, and this fact led us to study this relationship here in Ibb city-Yemen. Our study sample size was a total of 60 persons divided equally into two groups (30 healthy control persons and 30 chronic H. pylori infected patients), and each group was divided into 3 age groups (less than 40 years, 40-60 years, and more than 60 years). Also the sex was an important factor in study of such association. Frankly, the standard laboratory investigations used in diagnosis of PA (especially assessment level of serum vitamin B12 and intrinsic factor IF) were totally difficult to be done, especially in the past year due to hard, unusual, and killer conditions as a result of the war here in Yemen, so that, we simply examined the blood film microscopically for confirmation the presence of abnormal macrocytic red blood cells which later was used as a marker of PA. Even though our study sample size was so small in comparison to other studies, but we can say that results of our study surprisingly exhibited a very close agreement with results of other international published studies, since we founded that only 10% of chronic H. pylori infected patients were suffered from PA. Regarding the age we founded that all of the chronic H. pylori infected patients with PA (100%) were in the age group more than 60 years. The female sex, as we founded in our results was the most abundant among chronic H. pylori infected PA patients (11%) versus the male sex (10%). We finally strongly recommend the physicians and the patients themselves to use the typical drugs for eradication the chronic H. pylori infection for prevention of PA development and to avoid it's sever complications.

Association of Chronic H. pylori infection with Pernicious Anemia in Ibb City –Yemen