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The effects of ethanol extract of ripe fruits of Dennetia tripetala on prostatic and testicular functions of male albino Wistar rats were investigated. Twenty male albino rats weighing between 160 – 180g were divided into 4 groups with 5 animals in each group. Group 1 served as the control while Groups 2, 3 and 4 were orally administered 300 mg/kg, 600 mg/kg and 900 mg/kg of ethanol extract of ripe Dennetia tripetala fruits respectively daily for 28 days. Blood samples were collected through cardiac puncture, serum obtained for assay of prostate specific antigen (PSA) and testosterone levels while prostates and testes were excised and used for histological evaluation. The results showed a non-significant (P > 0.05) dose dependent decrease in the concentration of PSA. A non-significant decrease in testosterone levels in Groups 2 and 3 when compared to control was also recorded in this study while a significant decrease was observed in Group 4. Normal histological features were observed in the histology of the prostate while the presence of mature sperm cells in the photomicrograph of the testes of the treated groups suggest increased spermatogenesis following the administration of the extract. The results therefore suggest a beneficial effect of Dennetia tripetala in reducing PSA levels with possible improvement in spermatogenesis. It also showed no toxic effect on prostate and testes of the experimental animal.

Effect of ethanol extract of ripe fruits of Dennetia tripetala on prostatic and testicular functions of male albino rats