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The classical formulations are amended from time to time according to the need of healthy as well as disease conditions. This flexibility has insured its existence until today. Thalassemia is a genetic blood disorder. People with Thalassemia disease are not able to make enough hemoglobin, which causes severe anemia. Hemoglobin is found in red blood cells and carries oxygen to all parts of the body. When there is not enough hemoglobin in the red blood cells, oxygen cannot get to all parts of the body. Organs then become starved for oxygen and are unable to function properly. Gandhakadi Yoga is a customized preparation of the formulation proposed for Loha Sevanajanya Vikara Prashamana (iron overloading) in Ayurveda Prakasha. So in the present study the formulation Gandhakadi Yoga has been selected for clinical evaluation on patients of Thalassemia Major, against the standard conventional approach (i.e. Blood Transfusion & Iron chelation therapy). Aim and Objective: To evaluate the efficacy of Gandhakadi Yoga in the Management of Beejadushtijanya Pandu (Thalassemia Major). Material and Method: A 4 years old female patient from Jamnagar came in OPD of Kaumarbhritya department IPGT & RA, GAU, Jamnagar. Child was having complains of Panduta for 1, Hridravata for 1 year, Daubalya for 1 year, Aruchi for 1 yaer, Udarshool for 7 days. Gandhakadi Yoga in 2 divided doses orally with Sukhoshna Jala (Luke Warm Water) for 12 weeks, Follow up period 12 weeks. Result: Gandhakadi Yoga revealed marked improvement in features like Daubalya, Aruchi, Udarshool and Parameters such as Hematological and Biochemical. After 12 weeks of Follow up no any adverse effect during the course of study. Conclusion: This case study revealed that Gandhakadi Yoga is effective in Beejadushtijanya Pandu (Thalassemia Major). Marked improvement found in Subjective and Objective Parameters.