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Acute idiopathic thrombocytopenic purpura (ITP) is the most common bleeding disorder of childhood. Seventy percent of cases of acute ITP occur following viral illness. 1 Classically these infections include rubella, varicella, measles, and the Epstein-Barr virus.2 Acute ITP has also been reported after vaccination against poliomyelitis,3 measles,4-6 and rubella,7 (including combined measles-mumps-rubella [MMR] vaccination812), typhus-paratyphus,13 smallpox,14 and influenza and pneumococcal infections.15 The incidence of acute ITP following .MMR vaccination appears to be lower than that of acute ITP following natural rubella or measles infection.10,16-18 Nevertheless, the occurrence of acute ITP associated with .MMR vaccination is rare, and a limited amount of literature is published on the subject. This report describes a case of acute ITP developing 2 weeks after receiving the .MMR vaccine.

Acute idiopathic thrombocytopenic purpura following combined vaccination against measles, mumps, and rubella.