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Bone tissue undergoes continual remodeling through resorption and formation. The balance between these 2 activities is critical to optimizing bone mineral density (BMD) and the biomechanical integrity of the tissue, thereby reducing fractures. There is increasing evidence that diabetes negatively alters the cellular activity of bone tissue and reduces bone quality resulting in an increased risk of fractures. The mechanisms by which diabetes impacts bone are not completely understood; however, insulin, hyperglycemia, and glycation appear to influence skeletal regulation. This review will explore the influence of diabetes mellitus on bone as well as examine the potential methods by which exercise can serve as a nonpharmacological method to optimize bone health in persons with diabetes.

Diabetic Skeletal Health and Potential Benefits of Exercise