English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Human dermal exposure to diethylene glycol butyl ether (DGBE) and its acetate derivative (DGBA) may occur through contact with a variety of commercial products. Absorption and elimination of dermally applied doses of  14 C-DGBE and  14 C-DGBA were determined in Sprague-Dawley rats. The materials were applied under occlusion for 24 hr at dose levels of 0.2 and 2.0 g/kg (undiluted) and as a 10% aqueous solution (0.2 g/kg DGBE). Preliminary washing efficiency studies with soap and water indicated that greater than 89% of each chemical could be removed from rat skin following 5-min exposures. Female rats excreted a larger proportion of the applied dose of DGBE than did male rats. Similar results were obtained with the low dose of DGBE applied neat or as a 10% aqueous solution, suggesting that the low dose represents a saturating dose. The total recovered  14 C for all studies with  14 C-DGBE ranged from 83% to 89%, with  14 C-DGBA, from 80% to 88%. Urinary excretion accounted for the majority of recovered  14 C in all studies. The acid, 2-(2-butoxyethoxy)acetate acid was the major urinary metabolite identified. The glucuronide of DGBE was present at levels of from 5.2 to 8.2% of the urinary  14 C. The dermal absorption rates were estimated to be 1.58 (DGBA, male), 1.28 (DGBA, female), 0.73 (DGBE, male), and 1.46 (DGBE, female), expressed as mg/cm 2 /hr.

journal of the american college of toxicology

Toxicology of Diethylene Glycol Butyl Ether 2. Disposition Studies with 14C-Diethylene Glycol Butyl Ether and 14C-Diethylene Glycol Butyl Ether Acetate After Dermal Application to Rats