Open AccessTissue Reaction to Implantation of Collagen Film
Author(s) -
David Bergqvist,
Jeremy A. Falk,
Alexander Stahl
Publication year - 1977
Publication title -
upsala journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.808
H-Index - 41
eISSN - 2000-1967
pISSN - 0300-9734
DOI - 10.3109/03009737709179101
Subject(s) - medicine , biopsy , cystoscopy , phagocytosis , pathology , surgery , urology , immunology , alternative medicine
A new modified collagen film was investigated to evaluate the tissue reaction and absorption time (a) after implantation in rabbit muscle, and (b) in a human model where collagen was implanted in the prostatic cavity during operation. Clinical follow-up by cystoscopy and biopsy was made one week postoperatively. The animal results showed that for 6 weeks after implantation there was a cellular reaction associated with phagocytosis of the collagen film. Then a scar was formed, similar to that in the controls. The human results showed a similar tissue reaction and no adverse effects from the collagen film.