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Depression is a mental disorder, which encompasses emotion, cognition, and physical symptoms with considerable morbidity and mortality. In India, the lifetime prevalence of anxiety and depression is 24.4% and 18.5%, respectively, and co-morbidity of anxiety with depression is high about 87% (Sahoo and Khess, 2010). Stress is any transformation in environmental conditions that disturb the normal physiological equilibrium and linked to various neurological illnesses. Literature supports the role of inflammation and immune system deregulation in pathophysiology of depression (Raison et al. 2006;Leonard 2010). Clinical evidence suggested that antidepressant drugs are effective in treating depressive episodes, but less efficacious in recurrent depression and in preventing relapse (Fava and Offidani, 2011).

Reversal of neuro-inflammation and oxidative stress by polyherbal formulation in an animal model of chronic unpredictable mild stress