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Diabetes is a well known complex metabolic disorder manifested by fasting or postprandial hyperglycemia. Most common etiologies are insulin deficiency, impaired actions of insulin, and impairment in metabolic processes of the body. Secondary manifestation includes glucosuria, polyuria, polyphagia and muscle wasting. The disease is also associated with secondary complications such as nephropathy, retinopathy, hyperlipidemia, and cardiovascular diseases which play a major role in morbidity and mortality in diabetic patients (Bell, 1991; Bell and Polonsky, 2001). For a long time, many antidiabetic drugs are available to society however they present the concern of safety and thus make the disease treatment challenging to the medical professional (Holman and Turner, 1991). Ethnopharmacology witnessed the use of various herbs and their isolated constituents in diabetes treatment. Ayurvedic system of medicine in India has used various indigenous plants to treat diabetes in the era of Charaka and Sushruta. There are many phytoconstituents which are gaining popularity due to their ability to deal with various edges of chronic disorders such as diabetes. Additionally, they claim to have lesser adverse events (Grover et al., 1991; Swathi et al., 2018). Flavonoids are one of the phytoconstituents in the herbs which have proved their efficacy in the diabetes treatment through multiple mechanisms such as inhibition of glucose absorption, enhancement of glucose uptake, insulin mimetic effect, increase insulin secretion, antioxidant potential or by regulating the enzyme involved in carbohydrate metabolism (Babu and Gilbert, 2013). Gardenia gummifera (familyRubiaceae) is a shrub widely Antihyperglycemic, antihyperlipidemic and antioxidant effect of flavonoid rich extract of Dikamali in Streptozotocin-Nicotinamide-induced type II diabetic rats Sushama Dilip Patil , Rahul Somani , Ashish Jain 1, 2* 1 2

asian journal of pharmacy and pharmacology

Antihyperglycemic, antihyperlipidemic and antioxidant effect of flavonoid rich extract of Dikamali in Streptozotocin-Nicotinamide-induced type II diabetic rats