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Expectorants are drugs which enhance the secretion of the sputum bythe air passages so that it is easier to remove the phlegm through coughing. Theyare used in cough mixtures for this purpose they act either by increasing thebronchiole secretion or by making it less viscous. Expectorants are defined as medications that improvethe ability to expectorate purulent secretions. This term isnow taken to mean medications that increase airway wateror the volume of airway secretions, including secretagogues that are meant to increase the hydration of luminal secretions (eg, hypertonic saline or mannitol) and abhesives that decrease the adhesivity of secretions and thus unstick themfrom the airway (eg, surfactants) (Rubin, 2007). Cough is a natural protective reflex to remove airway secretions and pathogens from the respiratory tract, it is one of the common symptoms associated with chronic inflammatory disease of the respiratory tract such as asthma, chronic bronchitis, pneumonia and postnasal drip syndrome (Irwin and Madison, 2000). Cough can be regulated by medications such as codeine and dextromethorphan, which areassociated with side effects including drug dependency or drowsiness. Sputum tenacity, which results in adhesiveness and cohesiveness of sputum, considerably influences the clearance of sputum (Rubin, 1998). An expectorant is a drug that is thought to increase the hydration of either mucus or the periciliary fluid (Rubin, 2007). Although increasing hydration of the sputum itself will not improve clearance in the case of depleted airway surface liquid, improving the hydration of this surface fluid may detach secretions from the epithelium, thus decreasing tenacity and improving transportability and clearance of sputum (Donaldson et al., 2006; Ratjen, 2008). Therefore, there is aneed for herbal based expectorant with fewer adverse effects. Cough suppressant and expectorant activities of ethanolic extract of Pergularia daemia in mice model Prathap Balasubramaniyan , Jacob Varghese Powathikunnil , Sengottuvelu Singaravel 1* 1 2