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Melanogenesis is a physiological process resulting in the synthesis of melanin pigments which are responsible for skin pigmentation and provide a beneficial effect in preventing skin damage under normal conditions (Bonaventure et al., 2013). Tyrosinase is the rate limiting enzyme involved in melanin synthesis. Hence inhibition of tyrosinase in melanin pathway has become increasingly important for medicinal and cosmetic products used as powerful skin whitening agents for treating skin disorders (Nico Smit et al., 2009).

In silico analysis of the effect of vasicine and vasinone against human tyrosinase receptor in the management of hyperpigmentation of skin diseases