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The oral route of administration is deliberate as the most widely accepted route because of its feasibility of self administration, solidity and easy manufacturing (Sastry et al., 2000; Seager, 1998). Though, it is probable that at least 90% of all drugs used to produce systemic effects are administered by oral route. Continuation of drug delivery systems in the stomach prolongs overall GIT time recuperating oral bioavailability of the drugs that are having site specific absorption from the stomach or upper part of the small intestine. Consequently different approaches have been proposed to hold the dosage form in the stomach including swelling, bio adhesive systems, and expanding systems and delayed gastric emptying devices to achieve gastric dwelling time for sustained drug release (Gambhire et al., 2007). The objective of any drug delivery system is to provide a therapeutic amount of drug to the proper site in the body to attain rapidly and then continue the desired drug concentration (Gordon et al., 1990). This conscious control of drug release is achieved in sustained release dosage form as it prolongs the therapeutic effect by constantly releasing medication over an extended time after administration of a single dose (Vayas and Khar, 2002). The most employed method to adapt the sustained drug release is to include it in a matrix system. Matrix tablet is one of the most appropriate approaches for the preparation of the sustained release dosage forms. In real practice direct compression of drug, retardant material and additives is done to form a tablet in which drug particles are ingrained in the matrix core of the retardant. Dry or wet granulation technique may also be employed for the preparation of this type of tablets. Among the diverse approachs to prolong the drug action, formulation of matrix tablet has gained enormous popularity now days because it has the advantage of simple processing and a low cost of fabrication (Reddy et al., 2003)  .The loading dose is most suitable to include in a separate layer or in a coating applied to the tablet. An equation was developed by Higuchi (Higuchi, 1961; Higuchi, 1963) to Formulation development and evaluation of sustained release matrix tablets of Theophylline and Etophylline and study of polymers effect on dissolution rate  Mohammad Azaz Khan*, Senthil Selvi, P. Perumal

asian journal of pharmacy and pharmacology

Formulation development and evaluation of sustained release matrix tablets of Theophylline and Etophylline and study of polymers effect on dissolution rate